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Effects of norepinephrine on microglial neuroinflammation and neuropathic pain
He-Lin Zou1, Juan Li1, Jun-Li Zhou1
1Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical University Zunyi Guizhou China.
Abstract:
Norepinephrine (NE) is an important neurotransmitter in the central nervous system. NE is released from locus coeruleus neurons and is involved in a variety of physiological and pathological processes. Neuroinflammation is a common manifestation of many kinds of neurological diseases. The activation of microglia directly affects the status of neuroinflammation. Several kinds of adrenergic receptors, which anchor on microglia and can be regulated by NE, affect the activation of microglia and neuroinflammation. NE influences chronic pain, anxiety, and depression by regulating the activation of microglia.
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