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Updated: Jul 15, 2025

Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells

Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells

Published on: December 13, 2016

Magnetogenetic cell activation using endogenous ferritin.

Lisa Pomeranz¹, Rosemary Li², Xiaofei Yu³

¹Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA.

Biorxiv : the Preprint Server for Biology

|October 3, 2023

Summary

This summary is machine-generated.

Researchers developed a smaller magnetogenetics tool for precise cell control. This innovation enables magnetic activation of cells using adeno-associated virus (AAV) delivery and a novel benchtop electromagnet.

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Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

Area of Science:

Biotechnology
Neuroscience
Cell Biology

Background:

Precise control of cell activity is crucial for physiological studies and therapeutic development.
Existing magnetogenetic tools face limitations due to large construct sizes, hindering adeno-associated virus (AAV) delivery, and require complex magnetic field generation.

Approach:

Developed a novel anti-ferritin nanobody fused to the TRPV1 channel for efficient binding to endogenous ferritin.
Created a compact benchtop electromagnet for generating sufficient magnetic fields for *in vivo* applications.
Validated *in vitro* magnetic activation of cells using the nanobody-TRPV1 construct delivered via AAV.

Key Points:

The novel nanobody-TRPV1 construct is significantly smaller than previous tools, enabling single AAV delivery.
Demonstrated robust magnetically induced cell activation *in vitro*.
Successfully stimulated glucose-induced insulin release in pancreatic beta cells *in vivo*, improving glucose tolerance in mice.

Conclusions:

The new nanobody-TRPV1 construct and benchtop electromagnet enhance the practicality and applicability of magnetogenetics.
This advancement holds potential for both animal research and future human therapeutic strategies.
Improved magnetogenetics offers a powerful method for cell-specific modulation and opens new avenues in biomedical research.