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Published on: April 16, 2019
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Prevalence and Predictors of Nonalcoholic Steatohepatitis Using Multiple Non-Invasive Methods: Data from NHANES III.
Magda Shaheen1, Katrina M Schrode1, Dulcie Kermah1
1Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, USA.
Journal of Liver
|October 3, 2023
Summary
Non-alcoholic steatohepatitis (NASH) can be identified using non-invasive methods, which also revealed key risk factors. These combined approaches help screen individuals for potential NASH diagnosis and intervention.
Area of Science:
- Hepatology
- Diagnostic Medicine
- Public Health
Background:
- Nonalcoholic steatohepatitis (NASH) poses risks for cirrhosis and liver cancer.
- Liver biopsy, the current gold standard for NASH diagnosis, is invasive and expensive.
Purpose of the Study:
- To compare three non-invasive methods for identifying NASH.
- To determine NASH prevalence and associated variables using NHANES III data.
Main Methods:
- Utilized ultrasound data to identify moderate-to-severe hepatic steatosis.
- Applied HAIR score, NASH liver fat score, and Gholam score for NASH identification.
- Employed multinomial logistic regression for population comparisons.
Main Results:
- Identified 9.5% of subjects with NASH by at least one method; 1.8% by all three.
- Mexican-Americans exhibited the highest NASH prevalence across all methods.
- Significant risk factors included elevated waist-to-hip ratio, C-peptide, total cholesterol, and C-reactive protein (CRP).
Conclusions:
- Combined non-invasive methods effectively identify individuals with a high likelihood of NASH.
- Healthcare providers can use these methods for screening and identifying candidates for interventions or biopsy.
