Changes of bile lipid composition induced by methylprednisolone

Experiments were carried out on three groups of male guinea pigs to study the influence of methylprednisolone on the bile lipid composition. The cholesterol, phospholipid, and bile acids concentrations of the gallbladder bile in the control series were not significantly different from those of Group II, receiving SF for 45 days. In the methylprednisolone group, however, the absolute and relative molar concentrations of cholesterol increased while those of bile acids decreased compared to the former groups. Phospholipids on the other hand revealed only a relative increase. The observations indicate that use of methyl prednisolone for 45 days increases the lithogenicity of the bile in guinea pigs.