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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Jul 15, 2025

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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Research progress of stem cell therapy for ischemic stroke.

Ting Li1, Gao-Hong Zhu1

  • 1Department of Nuclear Medicine First Affiliated Hospital of Kunming Medical University Kunming Yunnan China.

Ibrain
|October 3, 2023
PubMed
Summary

Stem cell therapy shows promise for treating ischemic stroke by improving neurogenesis. This review covers its pathophysiology, clinical trials, and cell tracking advancements for better patient outcomes.

Keywords:
Cell TrackingIschemic StrokeMagnetic resonance imagingMolecular ImagingPositron emission tomographyStem cell therapy

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cerebrovascular Diseases

Background:

  • Ischemic stroke is a leading cause of death and disability worldwide.
  • Current treatments for ischemic stroke are limited, highlighting the need for novel therapeutic approaches.
  • The significant impact of stroke on patients, families, and society necessitates effective interventions.

Purpose of the Study:

  • To review the underlying pathophysiology of stem cell therapy in the context of ischemic stroke.
  • To discuss the impact of stem cell therapy on neurogenesis and brain repair.
  • To summarize recent clinical trials and advancements in tracking stem cells for ischemic stroke treatment.

Main Methods:

  • Literature review of preclinical and clinical studies on stem cell therapy for ischemic stroke.
  • Analysis of research on stem cell mechanisms, including neurogenesis and neuroprotection.
  • Examination of current and emerging techniques for tracking endogenous and exogenous stem cells.

Main Results:

  • Stem cell therapy demonstrates potential in promoting neurogenesis and functional recovery after ischemic stroke.
  • Various stem cell types are being investigated, each with unique therapeutic properties.
  • Advances in cell tracking technologies are crucial for understanding stem cell engraftment and efficacy.

Conclusions:

  • Stem cell therapy represents a promising therapeutic strategy for ischemic stroke.
  • Further research and clinical trials are needed to optimize stem cell treatments and monitoring.
  • Improved understanding and application of stem cell therapy could significantly reduce stroke-related morbidity and mortality.