Related Experiment Video
Updated: Jul 15, 2025
Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model
Published on: March 6, 2012
Comparative study of concurrent conventional chemoradiotherapy versus hypofractionated chemoradiotherapy in newly
Naresh Kumar Khatri1, H S Kumar1, Neeti Sharma1
1Department of Radiation Oncology, ATRCTRI, S.P. Medical College, Bikaner, Rajasthan, India.
Purpose:
To assess the treatment response and toxicity profile among two groups of newly diagnosed glioblastoma multiforme (GBM) postoperative patients receiving conventional radiotherapy (RT) versus hypofractionated RT with concurrent temozolomide (TMZ) in both.
Materials And Methods:
A total of 50 patients randomly allotted into two arms (25 in each). Dose received 60 Gy (2 Gy/#) in conventional fractionation RT versus 50 Gy (2.5 Gy/#) in hypofractionated RT with concurrent TMZ 75 mg/m2 orally daily in both arms, respectively. Follow-up was done at 1, 3, 6, and 12 months after completion of treatment to evaluate toxicities, treatment response, and progression-free survival (PFS).
Results:
All patients were well tolerated with treatment; no major adverse effects were monitored in two arms. There was no statistical significant difference in treatment response, which was found 64% versus 60% in arm A and arm B, respectively, at 3 months of follow-up (P = 0.768). Toxicity profiles were also noted similar in both arms. The 6-month PFS was 84% and 80% in arm A and arm B, respectively (P = 0.71) and 12-month PFS was 60% and 52% in arm A and arm B, respectively (P = 0.69).
Conclusion:
Among the patients followed, this study showed that hypofractionated RT regimen was not inferior to conventional RT regimen.
