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Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jul 15, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Disseminated malignant phyllodes: Presentation after a decade.

S Binitta Sherin¹, Leena Dennis Joseph¹, V Pavithra¹

¹Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Journal of Cancer Research and Therapeutics

|October 3, 2023

Summary

This summary is machine-generated.

Malignant phyllodes tumors of the breast are rare but can metastasize widely, even years later. Early diagnosis and aggressive management are crucial for improving survival rates in these aggressive breast cancers.

Area of Science:

Oncology
Pathology
Surgical Oncology

Background:

Phyllodes tumors are rare biphasic fibroepithelial breast lesions, comprising 0.3%-0.5% of primary breast tumors.

Keywords:

Distant metastases follow-up malignant phyllodes

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Malignant phyllodes tumors carry a significant risk (10%-26%) of distant metastasis, commonly to the lungs, bone, and soft tissues.