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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

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The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
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Related Experiment Video

Updated: Jul 15, 2025

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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Warthin-like papillary carcinoma thyroid.

Suman H Kalantri1, Lawrence D'Cruze1, G Barathi1

  • 1Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Journal of Cancer Research and Therapeutics
|October 3, 2023
PubMed
Summary

A rare variant of papillary thyroid carcinoma, Warthin-like papillary carcinoma, is often associated with Hashimoto

Keywords:
MalignancyWarthin-likerarethyroid

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Area of Science:

  • Endocrinology and Oncology
  • Thyroid Pathology

Background:

  • Solitary thyroid nodules necessitate investigation for malignancy, particularly in middle-aged women.
  • Papillary thyroid carcinoma is the predominant form of thyroid cancer, with Warthin-like papillary carcinoma representing a rare subtype.

Observation:

  • A 43-year-old female presented with a month-long neck swelling.
  • Fine-needle aspiration cytology indicated papillary thyroid carcinoma.
  • Biopsy confirmed the diagnosis of Warthin-like papillary carcinoma.

Findings:

  • Warthin-like papillary carcinoma frequently co-occurs with Hashimoto's thyroiditis.
  • This specific variant of papillary thyroid carcinoma is associated with an excellent prognosis.

Implications:

  • Accurate diagnosis of Warthin-like papillary carcinoma is crucial for patient management.
  • The excellent prognosis associated with this variant impacts treatment strategies and patient counseling.