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Leveraging existing 16S rRNA microbial data to identify diagnostic biomarker in Chinese patients with gastric cancer:
Jijun Chen1,2,3, Siru Nie1,2,3, Xunan Qiu1,2,3
1Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University , Shenyang, Liaoning, China.
Importance:
Gastric cancer is a significant and growing health problem in China. Studies have revealed significant differences in gastric microbiota between patients with gastric cancer and non-cancerous patients, suggesting that microbiota may play a role in tumorigenesis. In this meta-analysis, existing 16S rRNA microbial data were analyzed to find combinations consisting of five genera, which had good efficacy in distinguishing gastric cancer from non-cancerous patients in multiple types of samples. These results lend support to the use of microbial markers in detecting gastric cancer. Moreover, these biomarkers are plausible candidates for further mechanistic research into the role of the microbiota in tumorigenesis.
