Concurrent Medication Adherence in Hypertensive Patients With High-Risk Comorbidities

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Oonjee Oh, Kyoung Suk Lee

    The Journal of Cardiovascular Nursing
    |October 3, 2023
    PubMed

    Insights

    Patients with hypertension and multiple comorbidities face challenges with medication adherence. The study found an inconsistent relationship between the number of high-risk comorbidities and adherence levels.

    Area of Science:

    • Clinical Pharmacy
    • Health Services Research
    • Chronic Disease Management

    Background:

    • Hypertension management often involves multiple medications due to high-risk comorbidities.
    • Polypharmacy in patients with hypertension and comorbidities can increase the burden of medication adherence.
    • The number of chronic conditions is a potential factor influencing medication adherence.

    Purpose of the Study:

    • To compare characteristics of patients with hypertension and high-risk comorbidities based on medication adherence.
    • To investigate the association between the number of high-risk comorbidities and concurrent medication adherence.
    • To identify patterns in medication adherence among patients requiring multiple medications.

    Main Methods:

    • Secondary data analysis of the 2018 Korea Health Panel Survey.
    • Inclusion of 2230 patients with hypertension and at least one high-risk comorbidity on multiple medications.
    • Classification into adherent, suboptimal, and nonadherent groups based on medication adherence for each condition, analyzed using multinomial logistic regression.

    Main Results:

    • The adherent, suboptimal, and nonadherent groups comprised 85%, 11%, and 4% of patients, respectively.
    • More high-risk comorbidities were linked to the suboptimal adherence group (aOR=1.46) versus the adherent group.
    • Fewer high-risk comorbidities were linked to the nonadherent group (aOR=0.52) versus the adherent group.

    Conclusions:

    • Three distinct concurrent medication adherence groups were identified.
    • The association between the number of high-risk comorbidities and medication adherence groups was inconsistent.
    • Further research is needed to understand complex adherence patterns in this patient population.
    Abstract

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