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Using existing pediatric cancer data from the Gabriella Miller Kids First Data Resource Program

Alexandra Hudson1, Marcia Fournier2, James Coulombe2

  • 1Center for Research Strategy, National Cancer Institute, Bethesda, MD, USA.

JNCI Cancer Spectrum
|October 3, 2023
PubMed

Insights

The Kids First program offers a valuable data resource for childhood cancer and birth defect research. This initiative aims to uncover genetic causes and improve outcomes for affected children.

Area of Science:

  • Genomics
  • Pediatric Research
  • Bioinformatics

Background:

  • Childhood cancer and birth defects are significant causes of mortality in children.
  • Existing research suggests a link between birth defects and an increased risk of pediatric cancer.
  • The Gabriella Miller Kids First Pediatric Research Program (Kids First) was established to address these critical health issues.

Purpose of the Study:

  • To describe the data and support services offered by the Kids First Data Resource Center.
  • To introduce the Kids First Data Resource Portal as a public platform for accessing research studies.
  • To facilitate the investigation of the genetic etiology of pediatric cancer and birth defects.

Main Methods:

  • The Kids First Data Resource Center compiles genetic and clinical data from pediatric cancer and birth defect patients and their families.
  • The Kids First Data Resource Portal provides public access to review studies and request data.
  • Data integration with CAVATICA, a cloud-based analysis and sharing platform, enhances data accessibility and research capabilities.

Main Results:

  • The Kids First Portal hosts data from over 34,000 participants.
  • The portal connects researchers with a comprehensive dataset for investigating pediatric diseases.
  • The integrated platform supports diverse research inquiries into pediatric cancers and birth defects.

Conclusions:

  • The Kids First Portal is a unique, centralized resource for pediatric cancer and birth defect research.
  • Uniting genetic and clinical data aids in understanding the underlying causes of these conditions.
  • This resource has the potential to significantly improve the lives of children affected by cancer and birth defects.

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