Related Experiment Video
Updated: Jul 15, 2025
06:31
Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase
Published on: March 19, 2020
7.1K
Heteroleptic Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes: Structural Characterization, Computational
Abdollah Neshat1, Atiyeh Mahdavi2, Mohammad Reza Yousefshahi1
1Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), 444 Prof. Sobouti Blvd., Gava Zang, Zanjan 45137-66731, Iran.
Inorganic Chemistry
|October 3, 2023
Summary
New silver and gold complexes with sulfur ligands were synthesized and characterized. These metal complexes show potential anticancer and antibacterial activities, warranting further investigation for therapeutic applications.
Area of Science:
- Coordination chemistry and inorganic synthesis.
- Computational chemistry and electronic structure analysis.
- Medicinal inorganic chemistry and biological evaluation.
Background:
- N-heterocyclic carbene (NHC) metal complexes are of interest due to their diverse applications.
- Sulfur-donor ligands, such as dialkyldithiophosphates and bis(2-mercapto-1-methylimidazolyl)borates, can modulate the properties of metal complexes.
- Understanding the electronic structure is crucial for predicting and optimizing biological activity.
Purpose of the Study:
- To synthesize and characterize novel heteroleptic mononuclear silver(I) and gold(I) complexes.
- To investigate the electronic properties and structural features of the synthesized metal complexes.
- To evaluate the biological activities, including anticancer, antibacterial, antityrosinase, and hemolytic effects.
Main Methods:
- Synthesis of (NHC)M-Cl complexes (M = Ag, Au) with sulfur-donor ligands.
- Single-crystal X-ray diffraction for structural determination.
- Time-dependent density-functional theory (TD-DFT) and hole-electron analysis for electronic properties.
- In vitro biological assays against MCF-7 cancer cells, Gram-positive and Gram-negative bacteria.
Main Results:
- A series of heteroleptic mononuclear silver(I) and gold(I) complexes were successfully synthesized.
- Ag(I) complexes exhibited trigonal planar geometry, while Au(I) complexes showed near-linear geometry.
- Electronic structure analysis provided insights into the electronic features of the complexes.
- Preliminary biological screening indicated potential anticancer and antibacterial activities for selected complexes.
Conclusions:
- The synthesized NHC-metal complexes possess distinct structural and electronic properties.
- Selected complexes demonstrate promising in vitro anticancer and antibacterial activities.
- Further research is warranted to explore the therapeutic potential of these novel metal complexes.
More Related Videos
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
9.7K
07:07Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
9.7K
Related Concept Videos
02:52Stereoisomerism
12.0K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
12.0K
02:34Structural Isomerism
19.3K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.3K
01:19Complexation Equilibria: The Chelate Effect
546
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
546
00:39Complexometric Titration: Overview
7.3K
Complexometric titration involves the formation of a complex by reacting a metal ion with one or more ligands. A visual indicator often detects the end point of a complexometric titration. It is added to the metal solution before the titration, forming a stable metal–indicator complex and imparting color to the solution. As the titration approaches the equivalence point, the excess of the added ligand displaces the indicator from the metal–indicator complex, releasing the free...
7.3K
01:18Aromatic Hydrocarbon Cations: Structural Overview
2.8K
Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group...
Removing one hydrogen from the intervening CH2 group...
2.8K
03:45Formation of Complex Ions
23.7K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
23.7K