Related Experiment Video
Updated: Jul 15, 2025
12:44
Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
Published on: October 11, 2012
23.4K
Control of Cell Death in Health and Disease
Nobuhiko Kayagaki1, Joshua D Webster2, Kim Newton1
1Physiological Chemistry Department, Genentech, South San Francisco, California, USA;
Annual Review of Pathology
|October 3, 2023
Summary
Programmed cell death, including apoptosis, necroptosis, and pyroptosis, plays vital roles in health and disease. Modulating these cell death pathways offers therapeutic strategies for cancer and inflammatory conditions.
Area of Science:
- Cell Biology
- Immunology
- Pathology
Background:
- Programmed cell death encompasses apoptosis, necroptosis, and pyroptosis, crucial for eliminating damaged or infected cells.
- Apoptosis limits immune activation, while necroptosis and pyroptosis release inflammatory contents.
- Dysregulated cell death contributes to inflammation, cancer, and autoimmunity.
Purpose of the Study:
- To review strategies for modulating programmed cell death in disease contexts.
- To highlight the dual role of cell death in immunity and homeostasis.
- To explore therapeutic potential of targeting cell death pathways.
Main Methods:
- Review of scientific literature on programmed cell death mechanisms.
- Analysis of genetic studies in mice to understand cell death regulation.
- Examination of therapeutic agents targeting cell death pathways.
Main Results:
- Apoptosis is essential for development, homeostasis, and preventing cancer/autoimmunity.
- Necroptosis and pyroptosis contribute to pathogen clearance but can cause inflammation.
- Targeting cell death regulators shows promise in treating hematologic malignancies and inflammatory diseases.
Conclusions:
- Modulating apoptosis, necroptosis, and pyroptosis offers therapeutic avenues for various diseases.
- Venetoclax (BCL-2 inhibitor) demonstrates the clinical utility of apoptosis induction in cancer.
- Inhibiting necroptosis/pyroptosis pathways may alleviate inflammatory conditions.
More Related Videos
09:18Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
8.7K
10:03Author Spotlight: Understanding Cytokine-Induced Cell Death in Intestinal Epithelial Cells Using Human Organoids
Published on: August 2, 2024
1.5K
Related Concept Videos
01:30Overview of Cell Death
7.3K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
7.3K
01:30Apoptosis
11.6K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
11.6K
01:28The Cell Cycle Control System
3.0K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
3.0K
01:27Molecular Factors Affecting Cell Division
3.2K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.2K
01:17The Extrinsic Apoptotic Pathway
6.4K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.4K
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K