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FPL 57787 and migraine prophylaxis. A double-blind cross-over study.
Acta Neurologica Scandinavica
|March 1, 1979
Summary
This study investigated FPL 57787, a chromone derivative, for migraine prevention. The double-blind, placebo-controlled trial found no prophylactic effect in patients.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine is a common neurological disorder.
- Prophylactic treatments aim to reduce migraine frequency and severity.
Purpose of the Study:
- To evaluate the efficacy of FPL 57787 as a prophylactic agent for migraine.
Main Methods:
- A double-blind, cross-over trial was conducted.
- Fifteen patients with migraine participated.
- FPL 57787 was compared against a placebo.
Main Results:
- FPL 57787 demonstrated no significant prophylactic effect against migraine.
- No difference in migraine occurrence was observed between FPL 57787 and placebo.
Conclusions:
- FPL 57787 is not effective for migraine prophylaxis.
- Further research into chromone derivatives for migraine may be warranted, but this specific compound showed no benefit.