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Urinary tract infection in the context of mini-invasive procedures after kidney transplantation

Patricia Kleinova, Monika Beliancinova, Matej Vnucak

    Bratislavske Lekarske Listy
    |October 4, 2023
    PubMed
    Abstract

    Insights

    Antibiotic prophylaxis is not necessary for mini-invasive procedures like pig-tail extraction or protocol biopsy in kidney transplant patients. This study found no significant difference in positive urine cultures with or without antibiotic use.

    Area of Science:

    • Nephrology
    • Transplantation Medicine
    • Infectious Disease

    Background:

    • Antibiotic prophylaxis is standard for invasive procedures.
    • The necessity of antibiotic prophylaxis for mini-invasive procedures post-kidney transplantation remains unclear.
    • This study evaluated infectious complications during mini-invasive procedures without antibiotic prophylaxis.

    Purpose of the Study:

    • To determine the occurrence of infectious complications during mini-invasive procedures (pig-tail extraction, protocol biopsy) without antibiotic prophylaxis.
    • To identify risk factors for positive urine cultures during these procedures.

    Main Methods:

    • Prospective monocentric study including 68 kidney transplant patients.
    • Investigated positive urine findings at pig-tail extraction (6 weeks post-transplant) and protocol biopsy (3 months post-transplant).
    • Compared outcomes between patients with and without antibiotic prophylaxis.

    Main Results:

    • No significant difference in positive urine findings was observed between groups with and without antibiotic prophylaxis.
    • Patients without antibiotic prophylaxis showed higher tacrolimus and mycophenolic acid levels.
    • No monitored parameter, including antibiotic prophylaxis, was identified as a risk or protective factor for positive urine findings.

    Conclusions:

    • Antibiotic prophylaxis during mini-invasive procedures (pig-tail extraction, protocol biopsy) in kidney transplant recipients did not impact positive culture findings.
    • The center has discontinued the routine use of antibiotic prophylaxis for these specific procedures based on the study findings.
    Keywords:
    antibiotic prophylaxispig-tail extractionprotocol biopsy kidney transplantation.

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