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Leukocyte cell population data as potential markers of COVID-19 disease characterization

Giovanni Introcaso1, Arianna Galotta2, Laura Salvini3

  • 1Università di Milano, Centro Cardiologico Monzino IRCCS, Unit of Laboratory Medicine, Milan, Italy.

Journal of Medical Biochemistry
|October 4, 2023
PubMed

Insights

Leukocyte cell population data (CPD) showed increased cell activation in early COVID-19 waves, indicating worse clinical conditions. These hematological parameters can serve as valuable disease markers for risk assessment.

Area of Science:

  • Hematology
  • COVID-19 Research
  • Clinical Diagnostics

Background:

  • Hematological parameters are crucial in understanding COVID-19.
  • Leukocyte cell population data (CPD) is being explored for its clinical significance.
  • Previous studies highlighted the importance of hematological parameters during the COVID-19 pandemic.

Purpose of the Study:

  • To assess cell population data (CPD) in SARS-CoV-2 patients.
  • To evaluate CPDs as potential novel disease markers for COVID-19.
  • To compare CPDs between different waves of the COVID-19 pandemic.

Main Methods:

  • Enrolled 540 patients in the 1st wave (Feb-Apr 2020) and 2821 in the 2nd wave (Sep-Dec 2020).
  • Diagnosed SARS-CoV-2 using Multiplex rRT-PCR.
  • Analyzed CPDs with a Sysmex XN 2000 hematology analyzer and measured C-reactive protein (CRP) and lactate dehydrogenase (LDH).

Main Results:

  • Observed increased CPDs across all cell types in both waves compared to reference populations.
  • Found 9 CPDs elevated in the 1st wave versus 5 in the 2nd wave.
  • Noted significantly higher CPD values (NE-SFL, LY-Y, LY-Z, MO-X, MO-Y), CRP, and LDH in the 1st wave compared to the 2nd wave.

Conclusions:

  • CPDs indicated heightened cell activation in 1st wave patients, correlating with worse clinical outcomes.
  • CPDs serve as effective markers for disease characterization in COVID-19.
  • CPDs show potential utility in developing risk models for COVID-19 patients.
Abstract

Keywords:
COVID-19cell population dataclinical markersemergency departmentleukocyte parameters

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