Multimodal magnetic resonance imaging on brain structure and function changes in subjective cognitive decline: a...

Area of Science:

• Neuroimaging
• Neurology
• Alzheimer's Disease Research

Background:

• Subjective cognitive decline (SCD) represents the earliest symptomatic stage of Alzheimer's disease (AD).
• Early detection of SCD and its associated risk factors is critical for timely interventions aimed at delaying AD progression.
• Existing research extensively utilizes various neuroimaging modalities, including structural MRI (sMRI), diffusion tensor imaging (DTI), and functional MRI (fMRI), for SCD studies.

Purpose of the Study:

• To investigate structural and functional brain abnormalities associated with subjective cognitive decline (SCD).
• To explore the potential of advanced neuroimaging techniques for the diagnosis of SCD.
• To contribute to the early identification of individuals at risk for Alzheimer's disease.

Main Methods:

• Application of structural magnetic resonance imaging (sMRI) to assess brain structure.
• Utilized functional magnetic resonance imaging (fMRI) to evaluate brain function.
• Literature review of recent advancements in neuroimaging for SCD research.

Main Results:

• Identified specific abnormal brain structures in individuals with SCD using sMRI.
• Detected alterations in brain function patterns in SCD participants via fMRI.
• Findings suggest distinct neuroimaging biomarkers for SCD.

Conclusions:

• Structural and functional brain changes are detectable in the early stages of cognitive decline.
• sMRI and fMRI hold promise as diagnostic tools for subjective cognitive decline.
• Early neuroimaging-based diagnosis can facilitate targeted interventions for Alzheimer's disease prevention.