Related Experiment Video
Updated: Jul 15, 2025
05:37
Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
718
Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation
Bikash R Sahoo1,2, Vojč Kocman3, Nathan Clark1,2
1Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA.
Biorxiv : the Preprint Server for Biology
|October 4, 2023
Summary
The protein Znf706 promotes amyloid formation but is suppressed by G-quadruplexes. This interaction regulates protein folding and gene expression, revealing a broader role for SERF family proteins.
Area of Science:
- Molecular Biology
- Biochemistry
- Genetics
Background:
- The SERF protein family is known to accelerate amyloid formation.
- Znf706, a protein with homology to SERF proteins, is uncharacterized.
- The interplay between G-quadruplexes and protein aggregation/gene regulation is unclear.
Conclusions:
- Znf706 interacts with G-quadruplexes, modulating its function in protein aggregation.
- Znf706 and G-quadruplexes may regulate protein folding and gene expression.
- The SERF protein family, with G-quadruplexes, has a potential role in protein folding and gene regulation.
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