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Relationship between hepatitis C virus infection and extrahepatic malignancies
Hala I Mohamed1, Ehab M Abdelrahim1, Amr M Elsayed1
1Tropical Medicine Department, Faculty of Medicine, Minia University, Egypt.
Clinical and Experimental Hepatology
|October 4, 2023
Summary
Hepatitis C virus (HCV) infection is linked to a higher risk of developing lung, colorectal, pancreatic, and breast cancers. HCV positivity also reduced survival in colorectal and pancreatic cancer patients.
Area of Science:
- Hepatology
- Oncology
- Infectious Diseases
Background:
- Hepatitis C virus (HCV) is a major cause of liver disease globally.
- Emerging evidence suggests a connection between HCV and non-hepatic cancers.
- This study investigates the association between HCV and extrahepatic malignancies.
Purpose of the Study:
- To determine if HCV seropositivity correlates with the development of extrahepatic cancers.
- To assess the impact of HCV seropositivity on patient survival across different cancer types.
Main Methods:
- A retrospective case-control study comparing 1476 cancer patients (lung, colorectal, pancreatic, breast) with 1550 matched controls.
- Analysis of HCV seropositivity rates in cancer patients versus controls.
- Comparison of survival outcomes based on HCV serostatus within cancer subgroups.
Main Results:
- HCV seropositivity was significantly higher in the overall cancer group (11.6%) compared to controls (7.3%).
- Elevated HCV seropositivity was observed in lung (20.1%), colorectal (11.8%), pancreatic (25.4%), and breast cancer (8.1%) groups.
- HCV seropositivity correlated with reduced survival in colorectal and pancreatic cancers, but not significantly in lung or breast cancers.
Conclusions:
- HCV seropositivity is associated with an increased risk for developing lung, colorectal, pancreatic, and breast cancers.
- HCV infection negatively impacts survival in patients with colorectal and pancreatic cancers.
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