[Immunologic and pharmacologic activity of atropine-protein conjugates]

The immunological (production of specific antibodies to hapten) and pharmacological activity of bovine serum albumin conjugates with different chemical modifications of atropine was investigated. Mice and rabbits treated with atropine-protein conjugates (1-10 mg/kg) have produced a considerable number of specific serum antibodies to hapten during primary and secondary immune response. Mice treated with atropine-protein conjugates (25 and 50 mg/kg) have produced undetectable amounts of specific serum antibodies. The study of pharmacological activity in mice has revealed peripheral activity of atropine-protein conjugates. There was a correlation between the pharmacological activity of atropine-protein conjugates (25-50 mg/kg) and the activity of atropine (5 mg/kg), however the pharmacological effect of atropine-protein conjugates was somewhat longer. The results suggest that atropine-protein conjugates are both immunologically and pharmacologically active compounds.