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Updated: Jul 14, 2026
Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
Published on: April 10, 2019
Research Progress of Exosomal Non-Coding RNAs in Cardiac Remodeling
Yang Liu1, Xing Lyu2, Shengyu Tan1,3
1Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Abstract:
Exosomes are vesicles with a size range of 50 to 200 nm and released by different cells, which are essential for the exchange of information between cells. They have attracted a lot of interest from medical researchers. Exosomal non-coding RNAs play an important part in pathological cardiac remodelings, such as cardiomyocyte hypertrophy, cardiomyocyte apoptosis, and cardiac fibrosis. This review summarizes the origins and functions of exosomes, the role of exosomal non-coding RNAs in the process of pathological cardiac remodeling, as well as their theoretical basis for clinical application.
