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Updated: Jul 15, 2025

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A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
Published on: February 21, 2011
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Remote Assessment for ALS using Multimodal Dialog Agents: Data Quality, Feasibility and Task Compliance.
Vanessa Richter1, Michael Neumann1, Jordan R Green2
1Modality.AI, Inc., San Francisco, CA.
Summary
A conversational AI system effectively assessed speech in people with Amyotrophic Lateral Sclerosis (ALS), showing high task compliance and data quality for remote monitoring. This technology supports remote speech assessment in ALS patients.
Area of Science:
- Neurology
- Speech-Language Pathology
- Human-Computer Interaction
Background:
- Amyotrophic Lateral Sclerosis (ALS) progressively affects motor neurons, impacting speech.
- Remote assessment methods are crucial for managing ALS, especially for individuals with mobility challenges.
- Existing remote assessment tools may lack comprehensive speech function evaluation.
Purpose of the Study:
- To evaluate the feasibility, task compliance, and audiovisual data quality of a multimodal, dialog-based system for remote ALS assessment.
- To determine if speech severity or end devices impact the quality and compliance of remote recordings.
- To establish the utility of conversational agents for monitoring speech in ALS.
Main Methods:
- 53 individuals with ALS and 52 healthy controls interacted with a cloud-based conversational agent (Tina).
- Participants completed speech tasks designed to assess motor speech function.
- Audio and video recordings were collected and rated for quality and task compliance.
Main Results:
- Excellent participant compliance (98%) and high audio (95.2%) and visual (84.8%) quality rates were achieved.
- 80.8% of recordings were both compliant and of high quality.
- Recording quality and compliance were unaffected by speech severity or end devices.
Conclusions:
- Dialog-based systems are feasible and effective for remote speech assessment in ALS.
- The system demonstrates high data quality and participant compliance, supporting its use in remote monitoring.
- This approach offers a valuable tool for tracking speech changes in ALS patients remotely.

