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Cutaneous Intravascular CD-30-Positive Anaplastic Large Cell Lymphoma: A Case Report and Literature Review
Kiana Banafshay1, Dylan Maldonado1, Michelle Tarbox1
1Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, USA.
Cureus
|October 4, 2023
Summary
This study details a rare case of primary cutaneous intravascular anaplastic large T-cell lymphoma (ALCL) presenting as a skin nodule. The findings highlight the T-cell variant
Area of Science:
- Oncology
- Dermatology
- Hematology
Background:
- Intravascular cutaneous anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin lymphoma.
- It typically involves proliferation within dermal blood vessels, often presenting in the skin.
- Most intravascular lymphomas are B-cell in origin, making T-cell lymphomas exceptionally uncommon.
Observation:
- A case of an 87-year-old male with primary cutaneous intravascular anaplastic large T-cell lymphoma is presented.
- The initial manifestation was an erythematous, subcutaneous nodule on the right mid-abdomen.
- The lesion's presentation mimicked other dermatological conditions.
Findings:
- Immunohistochemical analysis revealed lymphoma cells positive for CD3 and CD30.
- The cells lacked expression of anaplastic lymphoma kinase (ALK), pan-cytokeratin, CD10, CD20, and SOX10.
- This immunophenotype supports a diagnosis of ALK-negative T-cell lymphoma.
Implications:
- This case expands the understanding of rare T-cell variants of intravascular ALCL.
- It underscores the importance of considering intravascular lymphoma in the differential diagnosis of cutaneous nodules.
- Reviewing and comparing similar cases aids in characterizing this extremely rare condition.
