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Patient Perception of Skin Cancer Reduction by Nicotinamide Correlates With Use.

Justine G Schneider1, Mandy Majidian2, Ronald L Moy3

  • 1Dermatology, The Ohio State University College of Medicine, Columbus, USA.

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|October 4, 2023
PubMed
Summary

Nicotinamide (Vitamin B3) use is linked to higher patient-perceived skin cancer risk reduction, especially for non-melanoma types. Increased patient education on oral nicotinamide benefits is crucial for skin cancer prevention.

Keywords:
basal cell carcinomamelanomanicotinamidenonmelanoma skin cancerskin cancerskin cancer preventionsquamous cell carcinomavitamin b 3

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Area of Science:

  • Dermatology
  • Nutritional Science
  • Oncology

Background:

  • Nicotinamide (Vitamin B3) demonstrates a 23% reduction in non-melanoma skin cancers.
  • Patient awareness of nicotinamide's skin cancer-reducing benefits remains low.
  • Understanding patient perceptions is key for effective counseling on oral supplements for skin cancer prevention.

Purpose of the Study:

  • To investigate the association between nicotinamide intake and its perceived effectiveness in reducing skin cancer risk.
  • To assess patient beliefs regarding nicotinamide's efficacy compared to sunscreen.

Main Methods:

  • An online survey was distributed to patients who underwent Mohs surgery in 2019.
  • Survey questions assessed nicotinamide usage, perceived efficacy versus sunscreen, and risk reduction beliefs.
  • Data from 50 patient surveys were analyzed.

Main Results:

  • Patients perceived nicotinamide offered a 31.2% risk reduction for basal cell carcinoma (BCC) and 30.2% for squamous cell carcinoma (SCC).
  • Respondents using nicotinamide reported significantly higher perceived risk reduction for BCC (41.2%) and SCC (38.3%).
  • 15.6% of participants believed nicotinamide was more effective than sunscreen for skin cancer prevention.

Conclusions:

  • Higher perceived risk reduction for non-melanoma skin cancers correlates with increased oral nicotinamide use.
  • Enhanced patient education is necessary to improve understanding and adoption of nicotinamide for skin cancer prevention.
  • Current patient perceptions may not fully align with the established benefits of nicotinamide.