Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bacterial Flora of the Large Intestine

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enhancing effects of Mycoplasma pneumoniae antigens on Th2-attracting chemokine responses by murine splenocytes.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026

Same author

Comparative study of gastric microbiota between patients with autoimmune gastritis and those with atrophic gastritis.

Scientific reports·2025

Same author

Establishment of a reference panel of Helicobacter pylori strains for antimicrobial susceptibility testing.

Helicobacter·2022

Same author

Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers.

Helicobacter·2022

Same author

Characterization of Reproductive Microbiota of Primiparous Cows During Early Postpartum Periods in the Presence and Absence of Endometritis.

Frontiers in veterinary science·2021

Same author

Pathogenic Characterization of <i>Clostridium perfringens</i> Strains Isolated From Patients With Massive Intravascular Hemolysis.

Frontiers in microbiology·2021

Search research articles

Related Experiment Video

Updated: Jul 15, 2025

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Microbial ecology between Clostridioides difficile and gut microbiota.

Shigeru Kamiya^1,2

¹Department of Infectious Diseases, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan.

Bioscience of Microbiota, Food and Health

|October 4, 2023

Summary

Clostridioides difficile infection (CDI) involves toxins and virulence factors. Restoring gut microbiota through fecal microbiota transplantation (FMT) or other methods shows promise for preventing and treating CDI.

Keywords:

Clostridioides difficile gut microbiota live therapeutic products microbial ecology pathogenesis

More Related Videos

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

Related Experiment Videos

Last Updated: Jul 15, 2025

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

Area of Science:

Microbiology
Gastroenterology
Immunology

Background:

Clostridioides difficile (C. difficile) causes antibiotic-associated diarrhea and colitis.
Key virulence factors include toxins (A, B, binary), spores, and biofilms.
Diagnosis relies on anaerobic culture and toxin detection (NAAT, ELISA).

Purpose of the Study:

To review the pathogenesis, diagnosis, and treatment of C. difficile infection (CDI).
To explore the role of gut microbiota in CDI.
To discuss microbiome restoration strategies for CDI.

Main Methods:

Literature review of C. difficile pathogenesis, virulence factors, and diagnostic methods.
Analysis of treatment options including antibiotics and microbiome restoration.
Examination of emerging therapies like fecal microbiota transplantation (FMT), probiotics, and live biotherapeutic products (LBPs).

Main Results:

C. difficile infection is linked to virulence factors and altered gut microbiota.
Antibiotics like metronidazole, vancomycin, and fidaxomicin are used for treatment.
Fecal microbiota transplantation (FMT) is effective for recurrent CDI prevention.

Conclusions:

Gut microbiota plays a crucial role in CDI pathogenesis.
Restoring gut microbiota is a promising strategy for CDI prevention and treatment.
Further research into microbial ecology can enhance understanding and management of CDI.