Related Experiment Video
Updated: Jul 15, 2025

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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
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Genome-Wide Association and Two-Sample Mendelian Randomization Analyses of Plasma Ghrelin and Gastrointestinal Cancer
Susanna C Larsson1,2, Jonas Höijer1, Jing Sun3
1Unit of Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Summary
Higher plasma ghrelin levels may reduce gastrointestinal cancer risk. This study used genetic data to investigate the causal link between ghrelin and cancer, finding a potential protective association.
Area of Science:
- Genetics
- Gastroenterology
- Oncology
Background:
- Observational studies suggest ghrelin is an early marker for gastrointestinal cancer.
- The causal role of ghrelin in gastrointestinal cancer development remains uncertain.
Conclusions:
- The study provides evidence supporting a causal link between elevated plasma ghrelin and reduced gastrointestinal cancer risk.
- Higher ghrelin levels may have a protective effect against gastrointestinal cancers.

