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Updated: Jul 15, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.3K
The Gut-brain Connection and Episodic Migraine: an Update
Linda Nguyen1, Nada Hindiyeh2, Sutapa Ray3
1Stanford University, Palo Alto, CA, USA.
Current Pain and Headache Reports
|October 4, 2023
Summary
Migraine and gastrointestinal (GI) disorders share links via the gut-brain axis. Tailoring treatments for episodic migraine patients with GI issues is crucial for effective management.
Area of Science:
- Neurogastroenterology
- Gut-Brain Axis Research
- Migraine Pathophysiology
Background:
- Migraine and gastrointestinal (GI) disorders frequently coexist.
- The gut-brain axis is increasingly recognized as a key factor in this comorbidity.
- Historical and recent evidence supports a shared etiology involving gut-brain interactions.
Purpose of the Study:
- To review recent literature on the gut-brain connection in migraine.
- To highlight the importance of considering GI comorbidities in episodic migraine management.
- To emphasize individualized treatment strategies for patients with overlapping symptoms.
Main Methods:
- Narrative review of current scientific literature.
- Analysis of population-based studies on migraine and GI disorder prevalence.
- Examination of clinical guidelines and perspectives on treatment.
Main Results:
- Migraine and GI disorders are common comorbidities with overlapping symptoms.
- Current guidelines (American Headache Society) incorporate GI symptoms into migraine diagnostics.
- Nonoral therapies are recommended, but nasal delivery may have GI-related adverse events.
- The gut-brain axis association with migraine is supported but complex and not fully understood.
Conclusions:
- Identifying GI symptoms and comorbidities is essential for personalized episodic migraine management.
- Treatment decisions for episodic migraine must carefully consider co-occurring GI issues.
- Further research is needed to fully elucidate the complex gut-brain axis relationship in migraine.
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