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Updated: Jul 15, 2025
07:36
Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
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Metal-Catalyzed Enantioconvergent Transformations.
Miguel Yus1, Carmen Nájera1, Francisco Foubelo1,2
1Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Alicante, Apdo. 99, E-03080 Alicante, Spain.
Chemical Reviews
|October 4, 2023
Summary
Enantioconvergent catalysis transforms racemic mixtures into single enantiomers using transition-metal catalysis. This review highlights recent advances in asymmetric synthesis, including cross-coupling and C-H functionalization methods.
Area of Science:
- Organic Chemistry
- Catalysis
- Asymmetric Synthesis
Background:
- Enantioconvergent catalysis is crucial for synthesizing single enantiomers from racemic compounds.
- Asymmetric synthesis aims to produce enantiomerically pure compounds, vital in pharmaceuticals and materials science.
Purpose of the Study:
- To review recent advancements in enantioconvergent catalysis.
- To cover transition-metal-catalyzed transformations for asymmetric synthesis.
Main Methods:
- Radical-based cross-coupling of racemic alkyl electrophiles and nucleophiles.
- Reductive cross-coupling of electrophiles using Ni/bis(oxazoline) catalysis.
- Enantioconvergent C-H functionalization of racemic substrates.
Main Results:
- Demonstrated enantioconvergent radical-based cross-coupling and reductive cross-coupling reactions.
- Showcased enantioconvergent C-H functionalization strategies.
- Highlighted hydroalkylation, hydrogen autotransfer, and other metal-catalyzed reactions like additions and hydroxylations.
Conclusions:
- Enantioconvergent catalysis offers powerful tools for asymmetric synthesis.
- Recent advances provide diverse methodologies for accessing single enantiomers from racemic starting materials.
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