Association Between Circulating Resistin Level and Preeclampsia: A Meta-Analysis.

Area of Science:

• Endocrinology
• Obstetrics
• Metabolic Syndrome

Background:

• Resistin, an adipokine, is implicated in obesity and metabolic disorders.
• Previous studies on resistin's role in preeclampsia (PE) pathogenesis yielded inconsistent results.
• A definitive assessment of circulating resistin levels in PE is needed.

Approach:

• Systematic review and meta-analysis of observational studies.
• Comprehensive search of Medline, Web of Science, and Embase databases up to April 2023.
• Random-effects model used to pool data from 18 datasets (16 studies).

Key Points:

• Meta-analysis revealed a statistically significant increase in blood resistin levels in women with PE compared to controls (SMD=0.35, p<0.001).
• Subgroup analyses indicated that study design, timing, resistin measurement methods, BMI matching, and quality scores did not significantly alter the outcome.
• Diagnostic criteria for PE may influence study results (p=0.001 for subgroup difference).

Conclusions:

• Women with preeclampsia exhibit significantly higher circulating resistin concentrations than healthy pregnant women.
• Elevated resistin is a consistent finding across diverse study characteristics, reinforcing its association with PE.
• Further research may explore the clinical utility of resistin as a biomarker for PE.