Enhancing long-term memory through strength training: An experimental study in adult and middle-aged rats

The study aimed to explore the impact of strength training on long-term memory in adult and middle-aged rodents, specifically male Wistar rats aged 9 and 20 months. These rats were divided into two groups: one sedentary (SED) and the other trained (ST) for a period of 12 weeks. The strength training involved squatting exercises using adapted equipment, while the sedentary group maintained their regular, non-exercised routine. Behavioral tasks assessing mobility, anxiety, and multiple facets of memory, such as object recognition memory (ORM), social recognition memory (SRM), and object location memory (OLM), were conducted post-training. The findings were promising, revealing a generally beneficial impact of strength training on memory tasks across both age groups. Specifically, the ORM tasks showed facilitated and improved learning in both adult and middle-aged rats that underwent training. In contrast, OLM displayed only a facilitatory effect in both age groups, meaning that while the trained rats learned the task, they did not outperform the sedentary group. For SRM, a facilitatory effect was observed only in the adult group. In addition to the cognitive benefits, strength training was found to have an anxiolytic effect in the 9-month-old rats and positively affected body mass and adipose tissue composition. Notably, the study correlated the strength gains from the training with improved performance in memory tasks. These outcomes provide crucial insights into the potential of exercise-based interventions to bolster cognitive health and mitigate age-related cognitive decline.