Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

6.2K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.2K
Nucleic acids02:43

Nucleic acids

163.4K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
163.4K
RNA-seq03:21

RNA-seq

10.0K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
10.0K
Nucleic Acids02:43

Nucleic Acids

44.3K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
44.3K
RNA Stability01:53

RNA Stability

33.6K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.6K
Ribozymes02:47

Ribozymes

12.3K
The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can...
12.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modified lateral decubitus position with endoscopic combined intrarenal surgery for the management of complex calculi in solitary kidneys.

BMC urology·2026
Same author

Doping effect on the electronic and optical properties of all-inorganic CsGeBr<sub>3-x</sub>I<sub>x</sub>.

Optics express·2026
Same author

Research advances in immune agonists and their nanoparticles for enhancing the immunotherapeutic efficacy of PD-1 inhibitors in malignancies.

Frontiers in oncology·2025
Same author

Molecular surfaces modeling: Advancements in deep learning for molecular interactions and predictions.

Biochemical and biophysical research communications·2025
Same author

Pressure-Induced Topological Phase Transition and Large Rashba Effect in Halide Double Perovskite.

The journal of physical chemistry letters·2024
Same author

Ultra-Wideband High-Efficiency Solar Absorber and Thermal Emitter Based on Semiconductor InAs Microstructures.

Micromachines·2023

Related Experiment Video

Updated: Jul 15, 2025

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

4.2K

Quantifying RNA structures and interactions with a unified reduced chain representation model.

Fengfei Wang1, Renjie Xia1, Yangyang Su1

  • 1Institute of Bioinformatics and Medical Engineering, School of Mathematics and Physics, Jiangsu University of Technology, Changzhou 213001, China.

International Journal of Biological Macromolecules
|October 4, 2023
PubMed
Summary

This study reveals RNA helices are key to RNA structure and stability. Other RNA motifs contribute to structural diversity through varied base interactions, highlighting the complex interplay governing RNA form.

Keywords:
Base-base interactionsCoarse-grained modelNon-redundant databaseRNA motifsRNA structures

More Related Videos

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

31.5K
Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
11:32

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

Published on: May 24, 2017

12.1K

Related Experiment Videos

Last Updated: Jul 15, 2025

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

4.2K
RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

31.5K
Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
11:32

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

Published on: May 24, 2017

12.1K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Ribonucleic acid (RNA) is crucial for cellular functions.
  • Understanding RNA structure and interactions is vital for RNA-based therapeutics.

Purpose of the Study:

  • To investigate structural features and interactions of common RNA motifs.
  • To analyze local structural features and base-base interactions in RNA.

Main Methods:

  • Utilized a unified five-bead model.
  • Employed a non-redundant database for analysis.
  • Examined five common RNA motifs: helices, hairpin loops, internal/bulge loops, multi-branched junctions, and terminal tails.

Main Results:

  • Identified a preference for helical structures in RNA backbone and base orientation.
  • Observed motif-specific and sequence-dependent base interactions.
  • Demonstrated that RNA helices provide dominant base pairing and stacking interactions.
  • Found diverse base-base interactions in non-helix motifs, contributing to structural variety.

Conclusions:

  • RNA structure complexity arises from the interplay of base-base interactions.
  • RNA helices are fundamental to RNA stability and structure.
  • Non-helix motifs add to RNA's structural diversity through varied interactions.