Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

5.3K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.3K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

4.1K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.1K
Production of Formed Elements01:34

Production of Formed Elements

1.4K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
1.4K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
Development of Blood Vessels01:07

Development of Blood Vessels

620
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
620
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hematopoietic stem and progenitor cell hierarchy is established by thrombopoietin-driven neonatal hematopoiesis.

Stem cell reports·2026
Same author

Tissue-scale mapping reveals a central role of hepatoblasts in the regulation of fetal liver hematopoiesis and stem cell maintenance.

Developmental cell·2026
Same author

Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4<sup>+</sup> T cells.

Science (New York, N.Y.)·2025
Same author

MAFB regulates hematopoietic stem cell proliferation and maintenance.

Scientific reports·2025
Same author

Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity.

Nature communications·2025
Same author

Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation.

Cell reports·2025

Related Experiment Video

Updated: Jul 15, 2025

Isolation of Murine Embryonic Hemogenic Endothelial Cells
08:56

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

11.5K

[Hematopoietic system formation during embryogenesis].

Tomomasa Yokomizo1

  • 1Department of Microscopic and Developmental Anatomy, Tokyo Women's Medical University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 4, 2023
PubMed
Summary

Hematopoietic stem cell development is more complex than previously thought, involving at least three distinct waves. Recent lineage tracing experiments reveal new insights into embryonic hematopoietic stem and progenitor cell behavior.

Keywords:
EmbryoHSC-independentHematopoietic stem cellLineage tracing

More Related Videos

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis
07:38

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis

Published on: November 3, 2017

8.5K
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

11.1K

Related Experiment Videos

Last Updated: Jul 15, 2025

Isolation of Murine Embryonic Hemogenic Endothelial Cells
08:56

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

11.5K
Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis
07:38

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis

Published on: November 3, 2017

8.5K
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

11.1K

Area of Science:

  • Developmental biology
  • Hematology
  • Stem cell research

Background:

  • Hematopoiesis is crucial for organismal growth and maintenance.
  • Embryonic hematopoiesis was traditionally divided into primitive and definitive stages.
  • Recent findings suggest a more intricate, multi-wave developmental process.

Conclusions:

  • Embryonic hematopoietic development is a complex, multi-wave process.
  • Lineage tracing experiments are critical for elucidating developmental dynamics.
  • Further research is needed to fully understand the behavior of early hematopoietic stem and progenitor cells.