Related Experiment Video
Updated: Jul 15, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
The Difference in Clinical Features between Small-Sized Soft Tissue Sarcomas and Benign Tumors
Keiichiro Iida1, Yoshihiro Matsumoto1, Akira Nabeshima1
1Department of Orthopaedic Surgery, Faculty of Medical Sciences, Kyushu University.
Small soft tissue sarcomas, especially on hands and feet, may present as painful tumors in younger patients. This highlights the need for careful evaluation of small tumors to avoid misdiagnosis.
Area of Science:
- Oncology
- Orthopedics
- Radiology
Background:
- Small tumors are often resected without thorough assessment.
- Lack of knowledge on small sarcoma features can lead to unplanned resections.
- This study compares small soft tissue sarcomas with benign tumors.
Purpose of the Study:
- To investigate the clinical features of small-sized soft tissue sarcomas.
- To compare these features with those of small benign soft tissue tumors.
- To identify potential indicators for malignancy in small tumors.
Main Methods:
- Retrospective analysis of 17 small soft tissue sarcoma cases (<2 cm).
- Comparison with 39 small benign soft tissue tumors (<2 cm).
- Investigated features included age, sex, pain, tumor size changes, and observation duration.
Main Results:
- In tumors on hands and feet, sarcomas were more common in patients <40 years (71% vs. 27%) and those experiencing pain (100% vs. 43%).
- No significant differences in investigated features were found for tumors on limbs and trunk.
- Clinical features were largely ineffective in distinguishing malignancy for most small tumors.
Conclusions:
- Painful tumors on the hands and feet in younger patients warrant increased attention for potential malignancy.
- Early identification of small soft tissue sarcomas is crucial.
- Further research may refine diagnostic criteria for small tumors.
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment

