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Related Experiment Videos

Two converging brainstem pathways mediating circling behavior.

E J Tehovnik, J S Yeomans

    Brain Research
    |October 22, 1986
    PubMed
    Summary
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    Stimulating the rostromedial tegmentum (RMT) and medial pons (PONS) causes ipsiversive circling, while stimulating the superior colliculus (SC) causes contraversive circling. This study confirms functional connections between these brain regions via myelinated axons.

    Area of Science:

    • Neuroscience
    • Motor Control
    • Behavioral Neuroscience

    Background:

    • Ipsiversive circling is induced by stimulating the rostromedial tegmentum (RMT) or medial pons (PONS).
    • Contraversive circling is induced by stimulating the superior colliculus (SC).
    • The functional connectivity between these brain regions was previously unknown.

    Purpose of the Study:

    • To investigate the functional connections between RMT, PONS, and SC.
    • To determine if stimulation-evoked action potentials collide between these sites, indicating functional connectivity.

    Main Methods:

    • The collision method was employed in rats.
    • Pairs of stimulation pulses were delivered to different brain sites (RMT-PONS, SC-PONS).
    • The degree of collision was assessed by measuring the frequency required for circling at varying conditioning-testing intervals.

    Related Experiment Videos

    Main Results:

    • Significant collision (46-62%) was observed between RMT and PONS.
    • Collision (15-29%) was also found between SC and PONS.
    • Connected sites were located along the medial tegmental tract and crossed tectospinal pathway, with conduction velocities ranging from 0.8 to 13.8 m/s.

    Conclusions:

    • The rostromedial tegmentum (RMT) and medial pons (PONS) are functionally connected.
    • The superior colliculus (SC) and medial pons (PONS) are functionally connected.
    • These connections are mediated by myelinated axons and play a role in mediating circling behavior.