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Updated: Aug 12, 2026

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Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies
Published on: December 15, 2014
Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor
Brain Research
|October 29, 1986
Abstract:
Nerve growth factor (NGF) was injected into the lateral ventricle (5 micrograms on 4 occasions) of rats which had previously sustained ibotenic acid-induced lesions of the nucleus basalis of Meynert. Lesioned, but vehicle-injected and sham-lesioned and vehicle-injected rats were run as controls. Infusion of NGF led to a significant recovery of cortical choline acetyltransferase and acetylcholinesterase activity 6 weeks, but not two weeks after the lesion.

