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Related Experiment Videos

Intraventricular bombesin can decrease single meal size in the baboon.

D P Figlewicz, A Sipols, D Porte

    Brain Research Bulletin
    |October 1, 1986
    PubMed
    Summary
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    Intraventricular bombesin significantly reduces baboon meal size, suggesting a central effect on appetite regulation. This finding highlights bombesin

    Area of Science:

    • Neuroendocrinology
    • Appetite Regulation
    • Gastrointestinal Physiology

    Background:

    • Previous research indicated that intravenous bombesin administration reduces meal size in a dose-dependent manner.
    • The mechanism by which bombesin influences feeding behavior, particularly its central versus peripheral effects, requires further elucidation.

    Purpose of the Study:

    • To investigate the efficacy of intraventricularly administered bombesin in reducing single meal size in baboons.
    • To compare the effects of central (intraventricular) versus peripheral (intravenous) bombesin administration on food intake.

    Main Methods:

    • Doses of bombesin ranging from 0.1 to 4 micrograms/kg were administered to baboons via both intravenous and intraventricular routes.
    • Single meal size was measured 30 minutes following bombesin administration.

    Related Experiment Videos

  • Comparative analysis of meal size reduction between central and peripheral administration routes.

    • Main Results:

    • Intraventricular administration of a median dose of 1 microgram/kg bombesin resulted in an approximate 50% decrease in 30-minute meal size.
    • Intravenous administration of the same median dose (1 microgram/kg) resulted in only a 25% decrease in meal size.
    • The greater effect observed with intraventricular administration suggests a central mechanism of action.

    Conclusions:

    • Central administration of bombesin in baboons effectively decreases meal size, indicating a role in appetite regulation.
    • The findings suggest that the anorectic effects of bombesin are mediated centrally and are not primarily due to peripheral leakage.
    • Bombesin's central action on meal size has implications for understanding neuroendocrine control of feeding behavior.