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Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
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Bulimia Nervosa01:30

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Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: Jul 15, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
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Microbiota-gut-brain axis drives overeating disorders.

Sijia Fan1, Weiwei Guo1, Dan Xiao1

  • 1Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230001, China.

Cell Metabolism
|October 5, 2023
PubMed
Summary

Alterations in gut bacteria contribute to overeating disorders (ODs) by affecting the gut-brain axis. Probiotic supplements can restore gut health and alleviate OD symptoms.

Keywords:
gut metabolismkynurenic acidmicrobiota-gut-brain axisneural circuitovereating disorders

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Area of Science:

  • Microbiome research
  • Neuroscience
  • Gastroenterology

Background:

  • Overeating disorders (ODs) are prevalent, with unclear pathological mechanisms.
  • Dieting history and stress are common triggers for ODs.
  • The role of the gut microbiota in ODs is not fully understood.

Purpose of the Study:

  • To investigate the role of intestinal microbiota in overeating behaviors.
  • To elucidate the gut-brain axis pathway involved in ODs.
  • To identify potential therapeutic targets for ODs.

Main Methods:

  • Studied overeating disorder (OD) mice and patients with bulimia nervosa (BN).
  • Analyzed changes in intestinal microbiota and metabolism.
  • Investigated the gut-brain axis via vagus nerve signaling.
  • Utilized probiotic transplantation and metabolite supplementation.

Main Results:

  • Altered gut microbiota and metabolism were observed in OD mice and BN patients.
  • These changes disinhibited vagus nerve terminals, leading to gut-brain axis hyperactivation.
  • Probiotic *Faecalibacterium prausnitzii* or metabolite supplementation restored gut-brain pathway activity.
  • OD symptoms were alleviated by these interventions.

Conclusions:

  • Gut microbiota alterations are a key factor in the pathogenesis of overeating disorders.
  • The microbiota-gut-brain axis plays a critical role in mediating energy balance.
  • Microbiota-targeted therapies show promise for treating overeating disorders.