Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CRISPR-Cas9: A cornerstone for the evolution of precision medicine.

Annals of human genetics·2018
Same journal

Authors' Reply "Synchronous Soft-Tissue Lesions in the Oral Cavity in an Adolescent".

Oral diseases·2026
Same journal

Neutrophils From Aged Individuals Release NETs to Impair Oral Wound Healing Through NLRP3 Activation.

Oral diseases·2026
Same journal

Comment on "Multimodal Deep Learning-Based Screening of Degenerative Temporomandibular Joint Disease Using 2D Radiography: A Cost-Effective and Low-Radiation Approach".

Oral diseases·2026
Same journal

Oral Lesions and Dental Status in Individuals Using Oral Tobacco-Free Nicotine Pouches.

Oral diseases·2026
Same journal

Comment on "Synchronous Soft-Tissue Lesions in the Oral Cavity in an Adolescent".

Oral diseases·2026
Same journal

Atypical Whitish Gingival Plaque.

Oral diseases·2026
See all related articles

Related Experiment Video

Updated: Jul 15, 2025

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA
11:15

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

Published on: May 21, 2015

11.1K

Single-cell sequencing, spatial transcriptome ad periodontitis: Rethink pathogenesis and classification.

Sleiman Razzouk1,2

  • 1Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, New York, USA.

Oral Diseases
|October 5, 2023
PubMed
Summary
This summary is machine-generated.

Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) offer new insights into periodontitis. These advanced techniques help understand cellular and gene changes for improved diagnosis and treatment outcomes.

Keywords:
genomicsperiodontal diseasesprecision medicinesingle‐cell sequencingspatial transcriptomics

More Related Videos

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

11.5K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

19.1K

Related Experiment Videos

Last Updated: Jul 15, 2025

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA
11:15

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

Published on: May 21, 2015

11.1K
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

11.5K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

19.1K

Area of Science:

  • Genomics
  • Immunology
  • Oral Biology

Background:

  • Periodontitis involves complex interactions between multiple cell types and gene expressions.
  • Resident and infiltrating immune cells play crucial roles in periodontal tissue homeostasis and response to bacterial insults.

Purpose of the Study:

  • To review the application of single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) in periodontitis research.
  • To explore the potential of linking cell populations and gene signatures to periodontitis pathogenesis for enhanced diagnosis.

Main Methods:

  • A comprehensive literature search was conducted in the PubMed database.
  • Keywords included "single cell sequencing" OR "spatial transcriptomics" AND "periodontitis" OR "gingiva" OR "oral mucosa".

Main Results:

  • The search yielded 486 articles, with 22 human studies selected after filtering.
  • scRNA-seq and ST have revealed novel cellular and molecular changes associated with periodontitis.

Conclusions:

  • These transcriptomic techniques provide valuable insights into periodontitis, aiding diagnosis and clinical outcomes.
  • While new cell and gene functions are identified, specific signatures for periodontitis are yet to be established.