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Related Experiment Video

Updated: Jul 15, 2025

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
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The relationship between anesthesia and melatonin: a review.

Rui Guo1,2, Junming Ye3, Baozhen Liao3

  • 1Department of Anesthesiology, First Affiliated Hospital of Gannan Medical College, Ganzhou, Jiangxi, China.

Frontiers in Pharmacology
|October 5, 2023
PubMed
Summary

Melatonin supplementation may benefit anesthesia patients by reducing anxiety, pain, and improving sleep. This hormone also shows potential immune-modulating and anti-tumor effects, especially for cancer surgery patients, though more research is needed.

Keywords:
anesthesiamelatoninperioperative administrationperioperative anti-anxietyperioperative sleep disturbances

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Area of Science:

  • Anesthesiology
  • Endocrinology
  • Sleep Medicine

Background:

  • Anesthesia and surgery can disrupt melatonin secretion, impacting circadian rhythms.
  • Disrupted melatonin leads to adverse effects like sleep disorders, pain, and neurocognitive dysfunction.
  • Melatonin is a hormone crucial for regulating sleep-wake cycles and has antioxidant and anti-inflammatory properties.

Purpose of the Study:

  • To review the multifaceted relationship between anesthesia and melatonin.
  • To explore the perioperative benefits of melatonin administration.
  • To highlight potential applications in cancer surgery.

Main Methods:

  • This study is a comprehensive review of existing literature.
  • It synthesizes findings on melatonin's effects on anesthesia-related outcomes.
  • The review examines preclinical and clinical evidence.

Main Results:

  • Perioperative melatonin administration shows promise in reducing anxiety, pain, and improving sleep quality.
  • Melatonin may decrease the incidence of postoperative delirium.
  • Emerging evidence suggests immunomodulatory and anti-tumor effects beneficial for cancer patients.

Conclusions:

  • Melatonin can be an effective adjuvant during the perioperative period.
  • Its benefits include anxiolysis, sedation, analgesia, and improved sleep.
  • Further research is necessary to establish optimal dosage, safety, and efficacy, particularly in cancer surgery.