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Understanding Post-Sepsis Syndrome: How Can Clinicians Help?
Elisabeth C van der Slikke1, Lise F E Beumeler2,3, Madlene Holmqvist4
1Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, 9713GZ, the Netherlands.
Infection and Drug Resistance
|October 5, 2023
Summary
Sepsis survivors often face long-term physical, cognitive, and psychological issues, known as post-sepsis syndrome (PSS). Understanding PSS is crucial for improving care and reducing readmissions for these patients.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Public Health
Background:
- Sepsis affects over 49 million people globally each year.
- Improved survival rates lead to a growing number of sepsis survivors.
- Post-sepsis syndrome (PSS) is increasingly recognized as a significant long-term consequence.
Purpose of the Study:
- To review current knowledge on post-sepsis syndrome (PSS).
- To highlight the importance of understanding PSS for improving clinical care.
- To identify key challenges and future directions in managing sepsis survivors.
Main Methods:
- This is a review article.
- It synthesizes existing literature on sepsis and post-sepsis syndrome.
- Focuses on clinical implications and patient outcomes.
Main Results:
- Post-sepsis syndrome encompasses a wide range of long-term physical, cognitive, and psychological impairments.
- PSS increases the risk of hospital readmission and reduces health- and life span.
- Causative factors and comprehensive symptom profiles of PSS require further elucidation.
Conclusions:
- A thorough understanding of PSS is essential for optimizing care for sepsis survivors.
- Clinicians must be equipped to manage the multifaceted long-term effects of sepsis.
- Further research is needed to develop targeted interventions for PSS.
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