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Drug therapy reviews: antirheumatic agents.
American Journal of Hospital Pharmacy
|May 1, 1979
Summary
This review covers rheumatic disease treatments, from simple analgesics to advanced corticosteroids. Aspirin is often preferred for inflammation, with other nonsteroidal anti-inflammatory drugs and parenteral therapies used as needed.
Area of Science:
- Rheumatology
- Pharmacology
Background:
- Rheumatic diseases encompass a range of inflammatory and autoimmune conditions.
- Understanding pathophysiology and symptoms is crucial for effective management.
Purpose of the Study:
- To review the drug treatment options for rheumatic diseases.
- To outline a stepwise approach to pharmacotherapy based on disease progression and patient response.
Main Methods:
- Literature review of antirheumatic drugs.
- Categorization of drugs based on chemical class and mechanism of action.
- Discussion of therapeutic sequencing.
Main Results:
- Simple analgesics (e.g., acetaminophen) are for early stages.
- Aspirin is a primary anti-inflammatory choice; nonsteroidal anti-inflammatory drugs (NSAIDs) like phenylpropionic and indole derivatives are alternatives.
- Parenteral gold compounds or penicillamine are considered for refractory cases, followed by antimalarials, corticosteroids, and immunosuppressives.
Conclusions:
- Drug selection for rheumatic diseases depends on disease stage, severity, and patient tolerance.
- A hierarchical treatment strategy is recommended, escalating therapy as needed.
- Corticosteroids and immunosuppressives are reserved for severe or refractory cases.