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Protein carboxyl methylase in asthenospermia
Clinical Reproduction and Fertility
|August 1, 1986
Summary
Protein carboxyl methylase (PCM) activity in sperm is linked to sperm immaturity, not directly to motility issues. Further research is needed to understand its complex role in male fertility.
Area of Science:
- Reproductive Biology
- Spermatozoa Function
- Enzymology
Background:
- Protein carboxyl methylase (PCM) is an enzyme involved in cellular processes.
- Asthenospermia, characterized by reduced sperm motility, is a significant factor in male infertility.
- The precise role of PCM in human sperm function remains unclear.
Purpose of the Study:
- To investigate the activity of Protein carboxyl methylase (PCM) in human spermatozoa.
- To explore the correlation between PCM activity and sperm motility in men with and without asthenospermia.
Main Methods:
- Enzyme activity assay for PCM in spermatozoa.
- Analysis of sperm motility parameters and morphology.
- Comparison of PCM levels in fertile men versus men with asthenospermia.
Main Results:
- PCM activity varied widely (14-635 pmol/min per 10(9) sperm) across individuals.
- Low PCM activity was observed in some men with mild idiopathic asthenospermia.
- High PCM activity was found in men with severe asthenospermia and zero motility, as well as in those with immature sperm forms.
Conclusions:
- PCM activity does not directly correlate with sperm motility or motility index.
- A correlation exists between higher PCM activity and an increased proportion of immature sperm forms.
- The relationship between PCM activity and asthenospermia is complex, potentially involving other seminal cells.