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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
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ABCA3 and LZTFL1 Polymorphisms and Risk of COVID-19 in the Czech Population

J A Hubacek1, T Philipp, V Adamkova

  • 1Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. jahb@ikem.cz.

Physiological Research
|October 5, 2023
PubMed

Insights

Rare ABCA3 gene variations significantly increase SARS-CoV-2 infection risk. This genetic factor, alongside clinical conditions, impacts COVID-19 susceptibility and severity, aiding in understanding disease progression.

Area of Science:

  • Genetics
  • Infectious Diseases
  • Epidemiology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in millions of deaths globally.
  • Genetic variability is recognized as a key factor influencing susceptibility and severity of COVID-19, alongside clinical risk factors.
  • Previous research has explored genetic associations with COVID-19 outcomes, highlighting the need for further investigation into specific gene polymorphisms.

Purpose of the Study:

  • To investigate the association between common polymorphisms in the LZTFL1 (rs11385942) and ABCA3 (rs13332514) genes and SARS-CoV-2 infection susceptibility.
  • To determine if specific genotypes or alleles of LZTFL1 and ABCA3 are predictive of COVID-19 infection or disease severity.

Main Methods:

  • Genotyping analysis of LZTFL1 (rs11385942) and ABCA3 (rs13332514) polymorphisms was performed.
  • Study included 519 SARS-CoV-2-positive subjects (asymptomatic, symptomatic, hospitalized survivors) and 2,592 controls.
  • Statistical analysis was used to compare genotype distributions and assess risk associated with specific alleles and genotypes.

Main Results:

  • Rare ABCA3 AA homozygotes showed a significantly increased risk of SARS-CoV-2 infection (P=0.003; OR=3.66).
  • A borderline significant difference in LZTFL1 rs11385942 genotype distribution was observed between SARS-CoV-2 positive subjects and the general population (P=0.04).
  • A nonsignificantly higher frequency of LZTFL1 minor allele carriers was noted among hospitalized COVID-19 patients.

Conclusions:

  • A common polymorphism in the ABCA3 gene appears to be a significant predictor of susceptibility to SARS-CoV-2 infection.
  • LZTFL1 polymorphisms may also play a role in COVID-19 susceptibility, though further research is needed to confirm this association.
  • Genetic factors, particularly ABCA3 variations, are important considerations in understanding individual differences in COVID-19 risk.

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