The influence of microbiota on ferroptosis in intestinal diseases

Area of Science:

• Cellular Biology
• Microbiology
• Gastroenterology

Background:

• Ferroptosis is a regulated cell death pathway involving iron, lipid peroxidation, and impaired antioxidant defenses.
• Metabolic pathways, including iron and lipid metabolism, are crucial for ferroptosis execution.
• Gut microbiota influences ferroptosis through its composition, functions, and metabolites.

Purpose of the Study:

• To review the mechanisms of ferroptosis.
• To explore the role of gut microbiota in ferroptosis.
• To highlight the therapeutic potential of microbiota modulation for intestinal diseases.

Main Methods:

• Literature review consolidating current knowledge on ferroptosis and gut microbiota.
• Analysis of the interplay between microbial factors and ferroptotic pathways.
• Identification of key molecules and pathways involved.

Main Results:

• Pathogenic bacteria generally promote ferroptosis, exacerbating diseases.
• Probiotics typically protect against ferroptosis and cell death.
• A strong association exists between gut microbiota and intestinal diseases.

Conclusions:

• Gut microbiota plays a significant regulatory role in ferroptosis.
• Targeting gut microbiota offers a promising strategy for managing ferroptosis-related intestinal diseases.
• Further research into microbiota-ferroptosis interactions is warranted for therapeutic development.