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Lactate promotes Salmonella intracellular replication and systemic infection via driving macrophage M2 polarization

Xinyue Wang1, Bin Yang1, Shuangshuang Ma1,2

  • 1The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, TEDA Institute of Biological Sciences and Biotechnology, Nankai University , Tianjin, China.

Microbiology Spectrum
|October 5, 2023
PubMed
Abstract

Insights

Macrophage-derived lactate fuels Salmonella growth and systemic infection by promoting M2 polarization. This lactate-induced M2 polarization is key to Salmonella

Area of Science:

  • Microbiology
  • Immunology
  • Metabolic pathways

Background:

  • Salmonella is a major enteropathogen causing systemic infections via macrophage survival and replication.
  • Lactate, an abundant metabolite during infection, can polarize macrophages towards an M2 phenotype.

Purpose of the Study:

  • To investigate the role of macrophage-derived lactate in promoting Salmonella intracellular replication and systemic infection.
  • To elucidate the mechanism by which lactate influences macrophage polarization and Salmonella growth.

Main Methods:

  • Utilized Salmonella infection models in macrophages.
  • Analyzed lactate production and its effect on macrophage M2 polarization.
  • Investigated the involvement of the Salmonella type III secretion system effector SteE.

Main Results:

  • Macrophage-derived lactate significantly promotes Salmonella intracellular replication and systemic infection.
  • Lactate, via Salmonella effector SteE, induces macrophage M2 polarization.
  • Lactate-mediated M2 polarization is essential for promoting Salmonella growth.

Conclusions:

  • Macrophage lactate is a critical factor in enhancing Salmonella virulence.
  • The interplay between lactate metabolism, macrophage polarization, and Salmonella pathogenesis offers new therapeutic targets.
  • This study reveals a novel metabolic interface in host-pathogen interactions.
Keywords:
Salmonellainfectionlactatemacrophage polarizationmacrophages

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