Related Experiment Video
Updated: Jul 14, 2025
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
11.5K
[The development of multiple sclerosis over the age of 50]
N Yu Lashch1, A E Pavlikov1, A N Boyko1,2
1Pirogov Russian National Research Medical University, Moscow, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|October 5, 2023
Summary
Multiple sclerosis (MS) can develop in individuals over 50. This article explores the unique aspects of late-onset MS, including diagnosis and treatment options for this growing patient population.
Area of Science:
- Neurology
- Immunology
Context:
- Multiple sclerosis (MS) is a prevalent neurological condition affecting working-age adults.
- Increasing life expectancy and advancements in disease-modifying therapies are leading to a growing number of older MS patients.
- The incidence of MS is rising globally and within the Russian Federation.
Purpose:
- To investigate the occurrence of MS in individuals over 50 years of age.
- To describe the specific characteristics of late-onset MS.
- To outline diagnostic and therapeutic strategies for older MS patients.
Summary:
- This review examines the potential for developing MS after age 50.
- It details the distinct clinical presentation, diagnostic challenges, and treatment considerations for late-onset multiple sclerosis.
- The article highlights the evolving demographic of MS patients due to improved management and increased longevity.
Impact:
- Provides insights into the diagnosis and management of a less-studied MS demographic.
- Informs healthcare providers about the specific needs of older adults with MS.
- Contributes to the understanding of MS progression and treatment efficacy in aging populations.
Keywords:
agebeta-interferon1acladribinedimethylfumaratedisease-modifying treatments (DMT)elderly patientsmultiple sclerosisnatalizumabteriflunomideyoung patientsMore Related Videos
05:44Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
Published on: October 13, 2023
1.5K
09:37A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
8.3K
Related Concept Videos
01:28Menopause
182
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
182
01:19The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
01:30Cognitive Development During Adulthood
129
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
129
01:29Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
02:20Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
01:26Aging
62
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
62