Related Experiment Video
Updated: Jul 14, 2025

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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
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Seed Becoming Soil: A New Paradigm of the Ewing Sarcoma Tumor Microenvironment
Christopher Kuo1,2, James F Amatruda1,2,3
1Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California.
Abstract:
Cells in the tumor microenvironment, including cancer-associated fibroblasts (CAF), contribute to tumor growth and immune evasion. A recent study of Ewing sarcoma identified "CAF-like" tumor cells that mimic the protumorigenic features of CAFs. These findings highlight the role of cell plasticity in tumor growth. See related article by Wrenn et al., p. 5140.

