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CircRNA in ocular neovascular diseases: Fundamental mechanism and clinical potential

Wenxin Zhang1, Yuxi He1, Yan Zhang2

  • 1Department of Ophthalmology, 2nd Hospital of Jilin University, Changchun 130041, Jilin, China.

Pharmacological Research
|October 5, 2023
PubMed

Insights

Circular RNAs (circRNAs) show promise for managing ocular neovascular diseases (ONDs). This review explores circRNAs

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Genetics

Background:

  • Ocular neovascular diseases (ONDs) cause significant vision impairment and blindness due to abnormal blood vessel growth.
  • Circular RNAs (circRNAs), non-coding RNAs, are increasingly recognized for their roles in biological processes, including angiogenesis.
  • Their association with ONDs makes them a key research focus for diagnosis and treatment.

Purpose of the Study:

  • To review the potential of circRNAs in the management of ONDs.
  • To elucidate the regulatory roles of circRNAs in the five phases of angiogenesis.
  • To analyze circRNA interactions in specific ONDs and their diagnostic potential.

Main Methods:

  • Literature review focusing on circRNAs and ONDs.
  • Analysis of circRNA regulation in angiogenesis.
  • Detailed examination of circRNAs in pterygium, corneal neovascularization, age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity.

Main Results:

  • CircRNAs play a regulatory role in angiogenesis, offering potential therapeutic targets.
  • Specific circRNAs are implicated in various ONDs, demonstrating their disease association.
  • CircRNAs show potential as diagnostic biomarkers for ONDs.

Conclusions:

  • CircRNAs represent a promising avenue for OND management strategies.
  • Further research is needed to bridge the gap between current findings and clinical applications.
  • Harnessing circRNAs could lead to novel diagnostic and therapeutic approaches for vision-threatening diseases.
Keywords:
AngiogenesisBiomarkerCircular RNAMiRNA spongeNeovascularizationOcular neovascular disease

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