Disposable rocking bioreactors: recent applications and progressive perspectives

Area of Science:

• Biotechnology
• Cell Biology
• Bioprocess Engineering

Background:

• Disposable rocking bioreactors are crucial for scaling up animal and plant cell culture.
• They enable the development of specific bioprocesses, including vaccine and chimeric antigen receptor (CAR) T-cell manufacturing.

Purpose of the Study:

• To highlight the established utility of disposable rocking bioreactors.
• To explore emerging applications and future potential of these systems.

Main Methods:

• Review of current bioreactor technology and applications.
• Analysis of future trends in cell-based therapies and bioprocessing.

Main Results:

• Disposable rocking bioreactors effectively support large-scale cell biomass propagation.
• Established use in manufacturing vaccines and CAR T-cells.

Conclusions:

• Disposable rocking bioreactors are versatile tools for current bioprocessing needs.
• Future applications are anticipated in regenerative medicine, metabolic response studies, continuous bioprocessing, and cell-free synthesis.