Related Experiment Video
Updated: Jul 14, 2025
05:51
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
Published on: May 3, 2018
17.5K
Paravascular fluid dynamics reveal arterial stiffness assessed using dynamic diffusion-weighted imaging.
Qiuting Wen1, Adam Wright1,2, Yunjie Tong2
1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
NMR in Biomedicine
|October 6, 2023
Summary
Paravascular cerebrospinal fluid (pCSF) dynamics reflect arterial pulse waves, with faster pulse propagation linked to aging and cognitive decline. This study highlights pCSF
Area of Science:
- Neuroscience
- Biomedical Engineering
- Radiology
Background:
- Cerebrospinal fluid (CSF) dynamics are crucial for brain health.
- Glymphatic system function is linked to arterial pulsatility.
- The relationship between paravascular CSF (pCSF) pulsation and arterial stiffness is unexplored.
Purpose of the Study:
- To investigate if pulsatile pCSF dynamics can infer pulse wave propagation and arterial stiffness.
- To evaluate the time shifts between pCSF waves and finger pulse waves.
- To assess the association of these time shifts with age and cognitive function.
Main Methods:
- Utilized dynamic diffusion-weighted imaging (dynDWI) to capture in vivo pCSF dynamics.
- Measured pCSF waves using dynDWI and finger pulse waves via a finger pulse oximeter.
- Analyzed time delays (TimeDelay) between pCSF and finger pulses in 36 participants (aged 18-82).
Main Results:
- Demonstrated a strong correlation between pCSF pulse and finger pulse (mean CorrCoeff = 0.66).
- Found a significant inverse association between TimeDelay and age, indicating faster pulse propagation with aging.
- Observed that shorter TimeDelay correlated with poorer cognitive function in older adults.
Conclusions:
- pCSF pulsation is a valid indicator of intracranial pulse wave propagation.
- The brain-finger pulse wave travel time is sensitive to aging and arterial stiffness.
- pCSF dynamics offer a novel pathway for assessing cerebrovascular health and cognitive function.
Related Concept Videos
01:17Assessment of Diffusion and Perfusion
995
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
995
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
14
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
14
01:19Assessing Blood pressure using a doppler ultrasound
1.4K
To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
1.4K
01:19Imaging Studies VII: Vascular Imaging
15
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
15